NOVEL DRUG DELIVERY SYSTEM
An Introduction
During the past three decades of pharma industry, drug delivery systems has made significant advances. The sustained release pellets are used as core for the manufacture of capsule pharmaceutical dosage form, in particular for oral controlled drug release formulations. Drug delivery has now came to be recognized as a means of optimizing therapy with established drugs through better understanding of their pharmacokinetics & toxicity. By the use of new Drug Delivery systems, the bioavailability can be enhanced the therapeutic index of drugs by site specific targeting can be increased. And facilitates to reduce and excellent patient compliance can be obtained.
Advantages Of Novel Drug Delivery Systems Over Conventional Tablet / Capsule Preparations:
- Reduction of adverse effects by preventing the peak plasma levels from exceeding the therapeutic range.
- Prevention of high localized concentration of a drug and thereby minimizing gastric irritation.
- Reduction in frequency of dosage, thereby enhancing patient compliance.
- Effective management of the disease condition by maintaining the blood levels in the therapeutic range from a longer duration.
- Avoidance of night-time dosing which otherwise disturbs the patient.
- To Extended/delayed release technologies can be tailored to the desired release profile for a given drug. The release characteristics are customized on its Pharmacokinetic profile and need of compliance and side effects in mind for patients.
- Our pellets containing appropriate active in percentage can be used to fill different strengths dosage form, thus avoiding repetitious & costly strength specific validations.
- Pellets filled in transparent capsules provide aesthetic appeal with differentiation for marketing advantage compared to conventional tablet and capsule.
Factors Affecting NDDS
- Physicochemical properties of a drug.
- Route of administration.
- Acute/Chronic therapy.
- Target sites.
- The patient.
- The disease state/level.
Modes of NDDS
- Targeted Durg Delivery System.
- Controlled Drug Delivery System.
- Modulated Drug Delivery System.
Facilities at TIMETECH LIFE SCIENCES LTD.
- SR Coated Pellets Ready to Fill in Capsules.
- Direct Compression Granules For Tablets.
- Finished Formulations of Capsules, Tablets and Sachets.
- High Production Capacities And Many More.
Advantages Of Novel Drug Delivery Systems
- Decreased dosing frequency.
- Reduced rate of rise of during concentration in blood.
- Sustained and consistent blood level within the therapeutic window.
- Enhanced bioavailability.
- To achieve a targeted drug release.
- Reduced side effects.
- Improved patient compliance.
- Optimum dose at the right time and right location.
- Efficient use of expensive drugs, excipients and reduction in production cost.
- Beneficial to patients, better therapy, improved comfort and standard of living.